First, Do No Harm was my first book. I'm on my 9th.
I learned much about writing with my first book and I've edited it enough that it turned out well.
My agent has been trying to get 5 manuscripts published, but it's tough going even though I've had good reviews.
In many ways, a flat out rejection feels better than a compliment then a rejection, but that's the publishing business (you never know what they really mean).
My 9th book is a psychological thriller and although I have a general outline in my mind, I'm not sure where it's going until the characters take me there.
If I didn't enjoy the process of writing, I would have quit a long time ago.